张翱简介

1988年9月至1992年7月，就读于四川师范学院（现西华师范大学）化学系，获学士学位； 1992年9月至1995年7月，就读于南开大学元素有机化学研究所，获硕士学位； 1997年10月至2000年10月，中科院上海有机化学研究所，获博士学位，导师为姜标研究员。 1995年7至1997年9月，在中科院上海有机化学研究所工作，任研究实习员。 2001年2月至2002年3月，在美国乔治敦大学（GeorgetownUniversity）医药中心作博士后访问学者； 2002年4月至2006年2月，在美国哈佛大学（HarvardUniversity）医学院工作，任哈佛医学院Instructor，McLeanHospital药物化学研究室AssistantDirector，美国化学会东北分会会刊《TheNucleus》副编辑； 2006年至今在中国科学院上海药物研究所工作，获中科院"百人计划"择优支持。

张翱研究组主要从事创新药物研发及相关基础研究，尤其是靶向G-蛋白偶联受体（GPCR）和酪氨酸激酶（RTK）新型小分子药物的设计与合成研究。主要是通过发展新颖简捷合成方法实现类药性优势骨架的高效合成，以及基于活性天然产物类药性骨架进行多样性合成和衍生化，结合现代药物结构优化策略，探索药物的结构与活性、结构与靶向性、结构与成药性等规律，进而开发具有抗神经退行性疾病和抗肿瘤活性的新型药物。研究组目前正在进行的研究课题主要有： 【1】具有抗肿瘤活性的类药性天然产物的合成及基于成药性的结构优化； 【2】靶向酪氨酸激酶或DNG修复等特异性或多靶性抑制剂抗肿瘤药物的设计与合成； 【3】靶向G-蛋白偶联受体小分子药物的设计及抗神经退行性疾病活性研究。

研究员；百人计划；国家杰出青年

中科院上海药物所研究员、博士生导师、研究组长

2004年获哈佛医学院McLeanHospital年度最高学术奖-ALFREDPOPEAWARD；同年还获得哈佛医学院McLeanHospital-ADAMCORNEELYOUNGINVESTIGATORAWARD；2010年获中科院“百人计划”终期评估优秀奖；2011年获国家杰出青年基金。

1、SELECTEDPUBLICATIONS ChengtangDu,FulongLi,XuefengZhang,WenxiangHu,QizhengYao,AoZhang.LewisAcid-CatalyzedCyclizationofGlycals/2-deoxy-D-ribosewithArylAmines:AdditionalFindingsonProductStructureandReactionDiastereoselectivity.J.Org.Chem JunSun,XuefengZhang,FulongLi,ChunyongDing,WenjuanWu,AoZhang.Base-promotedreactionofmethyl4,6-O-benzylidene-3-deoxy-hexopyranosid-2-uloseandvariousarylaminesTetrahedronLett. YuanxiangWang,JingAi,GangLiu,MeiyuGeng,AoZhang.Expeditiousone-potsynthesisofC3-piperazinyl-substitutedquinolines:keyprecursorstopotentc-Metinhibitors.Org.Biomol.Chem HaiZhang,NaYe,ShanglinZhou,LinGuo,LongtaiZheng,ZhiliLiu,BoGao,XuechuZhen,andAoZhang:IdentificationofN-Propylnoraporphin-11-yl5-(1,2-Dithiolan-3-yl)pentanoateasaNewAnti-Parkinson'sAgentPossessingaDopamineD2andSerotonin5-HT1ADual-AgonistProfile.J.Med.Chem AilingZhao,XinGao,YuanxiangWang,JingAi,YingWang,YiChen,MeiyuGeng,AoZhang:Discoveryofnovelc-Metkinaseinhibitorsbearingathieno[2,3-d]pyrimidineorfuro[2,3-d]pyrimidinescaffold.Bioorg.Med.Chem ZhiqingLiu,QingzhangZhu,FuyingLi,LinaZhang,YingLeng,AoZhang:N-(5-SubstitutedThiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)PropanamidesasGlucokinaseActivators.MedChemComm FulongLi,ChunyongDing,MeiningWang,QizhengYao,AoZhang:InBr3-CatalyzedGlycosidationofGlycalswithArylamines:AnAlternativeApproachToAccess4-Aminocyclopent-2-enones.J.Org.Chem YuanxiangWang,JingAi,YingWang,YiChen,LuWang,GangLiu,MeiyuGeng,AoZhang:Synthesisandc-Metkinaseinhibitionof3,5-di-and3,5,7-tri-substitutedquinolines:identificationof3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7-(trifluoromethyl)quinolineasanovelanticanceragent.J.Med.Chem NaYe,QianQianWu,LiyuanZhu,LongtaiZheng,BoGao,XuechuZhen,AoZhang:FurtherSARstudyon11-O-substitutedaporphineanalogues:IdentificationofhighlypotentdopamineD3receptorligands.Bioorg.Med.Chem. JingZhang,KuiWu,MeiningWang,JianqinJiang,AoZhang:FeCl3.6H2O-promotedskeleton-rearrangementof1-substituted-3-benzazepines:substrateextensionandproductutilization.Tetrahedron Tu,S.;Ding,C.;Hu,W.;Li,F.;Yao,Q.;ZhangA.Facilesynthesisofindole-orbenzofuran-fusedbenzo[a]carbazole-1,4-dionesusingatandemtwo-stepreactionsequence.MolDivers FuyingLi,QingzhangZhu,YiZhang,YingFeng,YingLeng,AoZhang:Design,synthesisandpharmacologicalevaluationofN-(4-monoand4,5-disubstitutedthiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamidesasglucokinaseactivators.Bioorg.Med.Chem ChunyongDing,ShanghuiTu,QizhengYao,FulongLi,YuanxiangWang,WenxiangHu,AoZhang:One-PotThree-stepSynthesisofNaphtho[2,3-a]carbazole-5,13-dionesUsingTandemRadicalAlkylation-Cyclization-AromatizationReactionSequence.AdvSynCatal ZhiliLiu,HaiZhang,NaYe,JingZhang,QianQianWu,PeihuaSun,LinyongLi,XuechuZhen,andAoZhang:SynthesisofDihydrofuroaporphineDerivatives:IdentificationofaPotentandSelectiveSerotonin5-HT1AReceptorAgonist.J.Med.Chem YiZhang,ZhaobinHan,FuyingLi,KuilingDingandAoZhang:Highlyenantioselectivehydrogenationofa-aryl-b-substitutedacrylicacidscatalyzedbyIr-SpinPHOX.Chem.Commun JingZhang,AoZhang:UnprecedentedFeCl3·6H2O-PromotedSkeleton-Rearrangementof1-Aryl-2,3,4,5-tetrahydro-1H-3-benzazepines:aNewStrategyfortheSynthesisofC-1QuaternaryTetrahydroisoquinolines.Chem.Eur.J FuyingLi,ChenleiYin,JieChen,JinggenLiu,XinXie,AoZhang:[6,7]-Heterocycle-Fused14-HydroxymorphinanDerivatives:Design,Synthesis,andOpioidReceptorActivity.ChemMedChem FuyingLi,ChenleiYin,JieChen,JinggenLiu,XinXie,AoZhang:SynthesisandSARstudyofopioidreceptorligands:momo-andbis-indolomorphinans.ChemBiolDrugDe ChunyongDing,ShanghuiTu,FuyingLi,YuanxiangWang,QizhengYao,WenxiangHu,HuaXie,LinghuaMeng,AoZhang:SynthesisStudyonMarmycinA:PreparationoftheC3’-DesmethylAnalogues.J.Org.Chem YuanxiangWang,AoZhang:Expeditioussynthesisof2,3-dihydro-2-alkoxy-3-methylenebenzofuransfromN-benzofuran-3-ylmethylN,N,N-trialkylammoniumbromides.Tetrahedron FuyingLi,ChenleiYin,JieChen,JinggenLiu,AoZhang:Synthesisandopioidreceptoractivityofindolopropellanes.Bioorg.Med.Chem.Lett JingZhang,HaiZhang,WenxianCai,LeipingYu,XuechuZhen,AoZhang:“Click”D1receptoragonistswitha5-HT1AreceptorpharmacophoreproducingD2receptoractivity.Bioorg.Med.Chem Xue-QinChen,JingZhang,JohnL.Neumeyer,Guo-ZhangJin,Guo-YuanHu,AoZhang,XuechuZhen:ArylbenzazepinesarepotentmodulatorsforthedelayedrectifierK+channel:apotentialmechanismfortheirneuroprotectiveeffects.PLoSOne Yu-JunWang,Yi-MinTao,Fu-YingLi,Yu-HuaWang,Xue-JunXu,JieChen,Ying-LinCao,Zhi-QiangChi,JohnL.Neumeyer,AoZhang,andJing-GenLiu:PharmacologicalCharacterizationofATPM,aNovelMixedAgonistandµAgonist/AntagonistThatAttenuatesMorphineAntinociceptiveToleranceandHeroinSelf-AdministrationBehavior.J.Pharm.Exp.Ther ZhiliLi,JingZhang,AoZhang:Designofmultivalentligandtargetingg-protein-coupledreceptors.CurrPharmDes JingZhang,BingXiong,XuechuZhen,AoZhang:DopamineD1receptorligands:Wherearewenowandwherearewegoing,Med.Res.Rev